Bio-Defense Solution for Animal Health &Production

Natural Bio-Defense Solution for Ultimate Pathogen Control: A Peace of Mind Solution

Data shows that dysbiosis disrupts the gut microbiota balance, increasing harmful bacteria and weakening the gut barrier, which allows pathogens to enter the bloodstream. This bacterial translocation triggers inflammation, damaging the gut lining and impairing nutrient absorption. The resulting energy diversion from growth to immune responses reduces feed efficiency and hinders overall poultry performance.

This inflammatory response not only stresses the immune system but can also affect respiratory tissues, making the lungs more susceptible to infections. Moreover, poor gut health reduces the production of beneficial metabolites, like short-chain fatty acids, that help regulate immune function in the lungs. As a result, poultry with compromised gut integrity are at a higher risk of respiratory diseases, which further impacts growth and performance.

We are pleased to introduce our bundled solution, "Natural Bio-Defense Solution for Ultimate Pathogen Control: A Peace of Mind Solution."

Combining probiotics with organic acids offers a natural, powerful solution for animal protein producers to reduce pathogens, improve gut health, and enhance performance. This synergy supports food safety, boosts immunity, and serves as an effective alternative to antibiotics.

This program offers:

1. Improved Nutrient and Calcium absorption due to digestibility enhancement.

2. Improved Digestibililty due to reduction of intestinal viscosity

3. Gut Health and Integrity

4. Pathogen Control: growth inhibition of Salmonella enteritidis, E. Coli, Clostridium

perfringens and Campylobacter.

5. Proven enzyme production: lipase, amylase, protease, phytase, cellulase, xylanase & β

glucanase.

6. Immune Modulation: enhancing responses in the gut and via the gut-brain axis and gut-lung axis.

7. Water and Feed Intake: animals remain hydrated and maintain consistent feed intake.

8. Support for antimicrobial Programs: This program is drug-free and antibiotic-free, making it valuable in meeting regulatory and consumer demands for antibiotic-free poultry production.

Product Overview

1. AquaSpore™: Is a natural probiotic for drinking water with a proprietary targeted bacillus technology with selected isolates of Bacillus amyloliquefaciens. The spores of the strain are stable and are recommended to improve performance (average daily body weight gain and feed conversion) in commercial poultry (replacement chickens, broilers, chickens, laying hens and breeding chickens, quails, ducks, pheasants), swine, livestock, aquaculture and all species for all stages of production.

Primary Benefits:

- Gut Integrity & Microbiome Balance: Enhances gut lining and maintains a balanced gut microbiome, crucial for nutrient absorption and overall animal health.

- Nutrient digestibility optimization: increased yield, ADG & body weight, better performance.

- Feed Efficiency Improvement & increased growth (Ca + P absorption).

- Enzyme production: Facilitates the natural production of digestive enzymes, improving nutrient utilization and feed conversion. Savings in feed, bone mineralization, with less dirty eggs in layers and better milk quality in dairy cows.

- Immune Modulation: Strengthens the immune response, reducing the incidence of respiratory disease by enhancing immune responses via the gut-lug axis. This axis allows gut microbiota to influence respiratory immunity, with beneficial metabolites that modulate inflammation and support lung defenses. The bacillus

strains in AquaSpore™ improve gut barrier integrity, reduce pathogen colonization, and stimulate immune substances like short-chain fatty acids (SCFAs), which support immune cell function and modulate inflammation, enhancing both gut and respiratory health. Anti-inflammatory & anti-oxidant effects.

- Bacteria growth inhibition: bacteriocins production, quorum quenching and outcompeting for food.

- Antioxidant & Anti-Inflammatory Properties: Reduces oxidative stress and inflammation, contributing to healthier, stress-resistant animals.

- Protein Binding & Mineral Absorption: Significantly improves protein utilization, as well as calcium and phosphorus absorption, leading to stronger bone development and higher-quality of eggs, milk, yield etc.

Application: AquaSpore™ is designed to promote gastrointestinal health and reduce pathogen load.
AquaSpore™ is administered through drinking water at a dose of 1 gr per house (up to a maximum of 1000 liters of drinking water), three times a week. This will guarantee that 10 mL of AquaSpore™ will provide the dose of 10^6 CFU (colony forming unit) per animal.

Primary Benefits:

- Gut Integrity

- Nutrient digestibility optimization: increased yield, ADG & body weight, better eggs, bone mineralization with less dirty eggs in layers and better milk quality in dairy cows.

- Feed Efficiency Improvement & increased growth (Ca + P absorption)

- Better immunity due to a healthy gut & lymphocyte cytokines production

- Anti-inflammatory & anti-oxidant effects

- Healthy microbiome - dysbiosis prevention

- Enzyme production, savings in feed- Bacteria growth inhibition: bacteriocins production, quorum quenching and outcompeting for food

- Reduction of oxidative stress

3. BioFort™: is a specialized product designed to enhance animal health, for use in animal health. It functions as an organic acid and essential oil-based supplement, providing multiple benefits including antimicrobial effects, support for gut integrity, and improvements in water consumption during critical periods like pre-slaughter feed withdrawal.

Key Ingredients:

Organic Acids:

- Lactic Acid: Known for its antibacterial properties and its role in energy metabolism.

- Acetic Acid: Provides antibacterial and antifungal effects.

- Propionic Acid: Inhibits the growth of bacteria and fungi, contributing to food

safety.

- Caprylic Acid: Unique in the market for its bactericidal and fungicidal activity; also affects viral particles by disrupting lipid envelopes and promotes hormone secretion that stimulates food consumption.

- Tannic Acid: Helps maintain intestinal integrity and reduces protean degradation, which is particularly useful during transport to slaughter, minimizing weight loss and supporting animal welfare.

Essential Oils and Compounds:

- Thymol and Carvacrol: Known for their antimicrobial properties.

- Vitamins (B3, B5, B12, C, and E): These vitamins support overall animal health and metabolic functions.

Minerals:

- Copper and Zinc Sulfate: These are included for their bioavailable forms, supporting various biological processes and enhancing overall health.

Primary Benefits:

- Antimicrobial Action: BioFort™ provides broad-spectrum activity against pathogens like Salmonella, E. coli, and Campylobacter, making it a valuable tool for food safety and reducing the risk of infections.

- Gut Integrity: It reduces cellular degradation during periods of feeding absence, such as transport, and helps maintain the bird's body weight during stress.

- Enhanced Water Consumption: During critical periods like pre-slaughter feed withdrawal, BioFort™ encourages animals to maintain hydration without causing diuresis (excessive urination).

- Economic Benefits: It helps animals maintain weight through improved hydration and gut integrity, which translates into better processing weights at slaughter and improved return on investment.

Application: Administered through drinking water once a week at a 1:128 dilution rate is recommended.

4. Bio-Defense Solution Program

- Route of administration: Drinking water

3 days of probiotic: AquaSpore™ + 1 day of BioFort™ for the complete treatment program. This is a cost-efficient, bundled approach for full-scale pathogen control and health optimization across your animal’s production.

Program Design

Administration Period: The combined solution is administered from day 1 with the probiotic and when high pathogen challenges need to be addressed BioFort™ can be used once a week. This will allow to target the critical stages of poultry development and health. Regular administration as indicated, ensures ongoing pathogen defense, leading to healthier animals and improved production outcomes.

Let’s talk about how the "Natural Bio-Defense Solution Program for Ultimate Pathogen Control" provides animals with a comprehensive, affordable, and effective strategy for managing pathogens and ensuring the long-term health. With an easy-to-follow administration plan and clear cost breakdown, this program offers animals’ producers peace of mind and sustained flock productivity.

We look forward to partnering with you in ensuring the health and success of your animal production operation.

Liliana Monroy, DVM, MBA

Natural Animals Health

Founder - CEO

Guillermo Tellez Isaias

Natural Animals Health

VP of Technical Operations & Innovation

FAQs

Got Questions? Find Answers to Common Feed Concerns Below!

How does the synergistic combination of spore-based probiotics and organic acids in the BioDefense program enhance animals' gut health and overall performance?

Combines spore-based probiotics and organic acids to optimize gut microbiota, improve digestion, inhibit pathogens, strengthen immunity, and enhance overall animal performance.

Spore-based probiotics stimulate gut-associated lymphoid tissue (GALT), boosting local and systemic immunity. They modulate the release of anti-inflammatory cytokines and enhance the bird's resistance to infections.

Organic acids act as prebiotics, feeding beneficial bacteria, which, in turn, produce short-chain fatty acids (SCFAs) that strengthen gut epithelial cells and immune responses.

What measurable improvements in growth rate, feed conversion ratio (FCR), or production efficiency have been observed with the implementation of the BioDefense Solution program?

Boosts growth rates, improves feed conversion ratios (FCR), reduces mortality, and minimizes pathogen shedding for better productivity and economic efficiency.

The BioDefense Solution Program programs typically show a 5–10% improvement in body weight compared to control groups, depending on baseline nutrition and management conditions.: A reduction of 3–8 points in FCR (e.g., from 1.70 to 1.62) is commonly reported, translating to lower feed costs per kilogram of weight gain. Reduction in mortality by 2–5%, attributed to better gut health and reduced pathogenic load.

In what ways does BioDefense demonstrate efficacy in controlling enteropathogens like Clostridium perfringens or Salmonella, compared to conventional methods?

Uses probiotics to outcompete pathogens and produce antimicrobials, like bacteriocins, while organic acids create a hostile environment for pathogens, secreting antimicrobial peptides and competitive exclusion, offering a sustainable antibiotic alternative.

What supports BioDefense's Solution Program sustainability and cost-effectiveness?

Enhances feed efficiency, lowers disease costs, reduces environmental impact, and mitigates antimicrobial resistance, ensuring long-term productivity.

Case Studies

1. Commercial Broiler Operations: A six-month study showed a 5% improvement in FCR and a 15% reduction in mortality rates in flocks using the BioDefense Solution Program compared to controls.

2. Antibiotic-Free Programs: Transitioning to the BioDefense Solution Program, it enabled a 40% reduction in overall production costs associated with health interventions in antibiotic-free systems.

How does BioDefense reduce antibiotic reliance while maintaining the animals' health?

Improves gut health, lowers pathogen loads, strengthens immunity, boosts biosecurity, and maintains productivity without antibiotics, aligning with global antimicrobial resistance goals.

How does the BioDefense Solution Program performs compared with the traditional methods?

The BioDefense Solution Program offers several advantages over traditional methods such as antibiotics or vaccines. It directly inhibits pathogens while fostering the growth of beneficial microbes, avoiding the microbiota disruption often caused by conventional approaches. With a minimal risk of resistance, it stands out compared to the higher resistance potential linked to traditional methods. The program is highly stable due to its spore-based probiotic formulation, surpassing the stability of live probiotics typically used. Additionally, it significantly reduces pathogen shedding, contributing to a positive environmental impact—an aspect often unaddressed by conventional methods. Click on the chart provided to see a detailed summary of these key comparative advantages.

FAQ image